Four Signs in the Mouth May Be Linked to Increased Risk of Colon Cancer
Recent research suggests a potential connection between specific types of bacteria commonly found in the mouth and the development of colon cancer. This discovery, published on March 20 in the journal Nature, could lead to less invasive diagnostic methods and recent therapeutic approaches for this common, yet often difficult-to-detect, cancer.
Colon cancer forms when abnormal cells grow in the lining of the colon. Whereas relatively common, early detection is challenging and typically requires procedures like colonoscopies or surgery. A recent rise in colon cancer rates among younger individuals has prompted researchers to investigate the underlying causes and preventative measures.
The study identified a particular subtype of Fusobacterium nucleatum, a bacterium often associated with dental plaque and gum inflammation, as being linked to colon cancer growth. Researchers at the Fred Hutchinson Cancer Center found that this bacterium, normally found in the oral microbiome, was present in colon tumors at a higher frequency than in healthy colon tissue. “This is particularly compelling because this microbe is not usually found in the digestive tract below the mouth in healthy people,” said Susan Bullman, a biologist at the Fred Hutchinson Cancer Center.
To further explore the relationship, the research team extensively sequenced Fusobacterium nucleatum within colon cancer tumors and investigated how the bacteria influence the intestinal environment. By analyzing the genomes of the bacteria found in colon tumors, they were able to compare them to those found in the mouth.
Previous research has indicated a link between severe gum disease and colorectal cancer. A study from Virginia Tech University, published in Science Signaling, revealed that a common oral bacterium can contribute to the spread of colorectal cancer cells and identified the underlying mechanisms. Read more about this research here.
Another study, also published in Science Signaling, further details how this oral bacteria can lead to the spread of colon cancer cells. Learn more about the mechanisms behind this process.
The findings from these studies suggest that targeting these bacteria could potentially eliminate tumors and offer a new avenue for treatment. More information about the connection between oral bacteria and colon cancer can be found here. These discoveries highlight the importance of understanding the complex interplay between the oral microbiome and overall health.
