A centuries-vintage Chinese medicinal root is gaining attention as a potential treatment for androgenetic alopecia (AGA), the most common form of hair loss, which affects millions worldwide. While medications like finasteride and minoxidil are frequently prescribed, many patients are seeking safer, more holistic options, prompting researchers to investigate traditional remedies.
A new scientific review suggests that Polygonum multiflorum, a root used in traditional Chinese medicine for over a thousand years to “blacken hair and nourish essence,” could offer a promising alternative for managing AGA. Hair loss can significantly impact quality of life, and finding effective treatments remains a key area of research.
Unlike many standard hair loss treatments that target a single biological pathway, Polygonum multiflorum appears to function through multiple mechanisms simultaneously. The review found that the herb helps reduce the effects of dihydrotestosterone, a hormone linked to follicle shrinkage, while as well protecting hair follicle cells from premature cell death. It activates key growth-related signaling systems, such as Wnt and Shh, and improves blood circulation in the scalp, potentially enhancing the delivery of oxygen and nutrients to hair follicles.
“Our analysis bridges ancient wisdom and modern science,” said Han bixian, the first author of the review published in the Journal of Holistic Integrative Pharmacy. “What surprised us was how consistently historical texts—from the Tang Dynasty onward—described effects that align perfectly with today’s understanding of hair biology. Modern studies now confirm that this isn’t folklore; it’s pharmacology.”
Researchers examined a wide range of evidence, including laboratory experiments, clinical observations, and historical herbal writings. This comprehensive approach suggests the treatment does more than simply unhurried hair loss.
The review emphasizes that Polygonum multiflorum may actively support hair regeneration. Instead of merely slowing down further hair loss, the herb appears to stimulate new growth by influencing various growth factors and signaling pathways involved in the hair cycle. This broad approach could make it more effective than treatments focused on a single biological target.
“When properly processed—a key step in traditional preparation—the herb shows a favorable safety profile, making it more acceptable to patients wary of side effects like sexual dysfunction or scalp irritation linked to current medications,” the review highlights. This finding addresses a common concern among individuals seeking hair loss treatments.
The authors caution that further high-quality clinical trials are needed to confirm these results and determine the optimal use of Polygonum multiflorum. Although, the review underscores how careful scientific study of traditional remedies can open doors to new treatment strategies for common conditions like AGA. More research could solidify its place as a viable option for those seeking alternative hair loss solutions.
