Paracetamol Use During Pregnancy Not Linked to Autism or ADHD, Major Review Finds
A comprehensive review of existing research published today, November 10, 2025, has found no convincing evidence linking paracetamol use during pregnancy to an increased risk of autism or ADHD in children, offering reassurance to expectant mothers.
The research, published in the British Medical Journal, analyzed nine systematic reviews encompassing 40 observational studies. Researchers concluded the quality of evidence was consistently low to critically low, and any perceived association between paracetamol and neurodevelopmental conditions was likely attributable to genetic factors and other shared familial influences. This finding directly addresses concerns raised in recent years, including statements made by the previous US administration urging caution regarding paracetamol use during pregnancy.
“Women should know that the existing evidence does not really support a link between paracetamol and autism and ADHD,” stated Prof. Shakila Thangaratinam, a consultant obstetrician and senior author on the review at the University of Liverpool. “If pregnant women need to take paracetamol for fever or pain then we would say please do, particularly because high fever in pregnancy could be dangerous to the unborn baby.” The review also noted that alternative painkillers like ibuprofen are not recommended during pregnancy. For more information on medication safety during pregnancy, resources are available from the American College of Obstetricians and Gynecologists.
Researchers highlighted that one study examining data from 2.4 million Swedish children showed a marginal increase in autism, ADHD, and intellectual disability among those whose mothers used paracetamol during pregnancy, but this effect disappeared when comparing siblings with differing exposure levels. This suggests a stronger role for inherited genetics. The findings are particularly important as rising rates of autism diagnoses are often attributed to increased awareness and changes in diagnostic criteria, as discussed by the Autism Speaks organization.
Experts confirmed the review reinforces existing medical consensus, and officials advise pregnant women to continue following their doctor’s guidance regarding pain and fever management.
