A newly discovered scientific link suggests a protein produced by the liver plays a critical role in maintaining bone strength in men. The findings, reported by Наука Mail, could offer new insights into the causes of osteoporosis and related bone diseases.
Researchers at McGill University in Canada led the study, which found that certain enzymes and proteins secreted by the liver are involved in regulating bone formation in males – a connection not observed in females.
Laboratory Study on Mice
To reach these conclusions, the research team conducted a laboratory experiment using mice. During the experiment, they disabled the gene responsible for producing a protein known as fibronectin in the liver.
The results showed that:
Male mice experienced more brittle and weaker bones after the gene was deactivated.
No significant changes were observed in the bones of female mice.
These results indicate that liver-produced fibronectin protein may be an important factor in maintaining bone strength in males.
The relationship between fibronectin protein and osteoporosis (Image source: Wikipedia)
What is Fibronectin Protein?
Fibronectin is a protein found in the blood and participates in several vital processes within the body, including the construction of various tissues.
Regarding bones, this protein accumulates within bone tissue and contributes to the process of bone formation, and strengthening.
Studies have also shown that levels of fibronectin in the blood are higher in men than in women, which may explain the difference in its effect between the sexes.
Liver Disease May Affect Bone Strength
The study’s findings suggest that liver damage may lead to decreased levels of fibronectin in the blood, potentially weakening bones over time. This discovery could help explain why doctors observe decreased bone density in some men with liver disease.
Osteoporosis in Men
Medical statistics indicate that approximately 60% of osteoporosis cases in men are linked to other underlying health conditions.
Unlike women, where the disease is often associated with a decline in estrogen levels after menopause, the precise causes of bone mass loss in men after age 50 remain incompletely understood. This new scientific discovery may help clarify part of this mechanism.
Osteoporosis: A Widespread Condition
Osteoporosis is a common health problem worldwide. Estimates suggest that:
Approximately one-third of women
and one in five men
may experience fractures during their lifetime as a result of this disease.
Recent research indicates that osteoporosis is not merely a disease affecting the bones, but a complex health condition that can be influenced by the function of other organs in the body, such as the liver.
